Startup News: Lessons and Tips for Entrepreneurs from a Strange Case Study in 2025

A live, four-inch parasitic worm migrated from a woman’s forehead to her eyelid. Prompt surgical removal by doctors ensured a full recovery, raising awareness on mosquito-borne infections.

F/MS LAUNCH - Startup News: Lessons and Tips for Entrepreneurs from a Strange Case Study in 2025 (F/MS Startup Platform)

The story of a woman having a four-inch worm hatch from her forehead and finding its way to her eyelid isn’t just an eerie medical tale; it also sheds light on how assumptions can lead to unexpected challenges. As I navigated this peculiar case study, I couldn’t help but connect it to the hurdles that startup founders, particularly women in Europe, often face when venturing into uncharted territory with innovative ideas.

The Anatomy of Risk and Uncertainty

In the realm of entrepreneurship, many of us discover risks that, at first glance, appear controllable, much like encountering a mosquito bite. Over time, however, these small setbacks can mutate into larger, more complicated challenges if not addressed early. Take the example in this medical case where the unwelcome parasite, Dirofilaria repens, thrived because it found a conducive host. Similarly, weak processes in a startup or ignored market signals can grow and spread, creating havoc across your business model.

Understanding the root of risks and addressing them at their onset is key. Ignoring them could mean facing a problem buried deeper in your business. For us founders, it’s our responsibility to examine every nodule of our operations closely even before it wanders into something far more disruptive, like crawling its way to the sensitive “eyelid” of our venture where it can leave damaging scars.

A Practical Framework for Handling the Unforeseen

Here’s a guide on tackling such entrepreneurial infections before they spiral out of control:

  1. Track movements across your "forehead" early: Much like monitoring that nodule in its early stages, do a monthly check on weaker areas of your startup. Whether it’s tracking user feedback, correlating revenue dips, or evaluating team exhaustion, paying attention to detail reveals looming concerns.

  2. Don’t dismiss bumps that you assume will ‘go away’: The moment you spot something amiss, act. Whether it’s communication breakdowns within your team or a product flaw amplified by frustrated customer reviews, taking immediate steps ensures your resources aren’t drained later.

  3. The importance of specialists: Just as the Romanian woman’s worm problem required a specific medical specialist to diagnose and remove it, your startup might need external advisory or mentorship to excise unproductive methods or processes. Learn what’s best on picking a mentor or advisor from sources like How to Choose Business Mentors for Female Founders.

  4. Learn the lifecycle of risks: In the case of the parasite, mosquitoes acted as carriers. For startups, what are those "mosquitoes" within the ecosystem that nurture risks? Keep tabs on weak partnerships, market dependency on outside-forces, lack of contingency plans during economic downturns, and other elements that could leave you struggling like a host wondering where things went wrong.

Lessons to Carry Forward as a Female Entrepreneur

The insights from this story, and my own experience building startups, include some tough yet necessary truths in the entrepreneurial process:

  • Don't settle when diagnosing the challenge: The woman had to visit specialists to identify the exact problem. Don't oversimplify underlying business issues, dig deeper.

  • Understand the environments you operate in: Just as the parasite thrives in specific climates dictated by the mosquito species that spread it, startups flourish in spaces that are suited to their vision. Knowing your ecosystem, whether it's the European market landscape or the lean startup community, is non-negotiable.

  • The importance of adaptability: The parasite maneuvered its way across the human body, looking for survival zones. Adaptability is great for startups too, but only when done consciously. Chasing trends or erratic pivots without structure can lead to mission drift.

Mistakes Entrepreneurs Should Avoid

Drawing parallels, here’s a list of avoidable missteps:

  1. Ignoring Threats: Neglected diseases grow worse, and so do unaddressed business risks. Spotting market threats or gaps in your value chain requires constant diligence.
  2. Assuming you won’t be the exception: The woman in Romania likely never thought she'd be the unfortunate host of a rare infection. As an entrepreneur, don’t assume your specific situation is safe from market fluctuations or competitors. Challenge that thinking.
  3. Reacting too late: Timely action could prevent expensive fixes, whether you’re rebranding after a failed launch or making larger marketing adjustments after mistakenly targeting the wrong demographic.
  4. Avoiding iterative learning: If you see movement under the surface, test your solutions until clarity surfaces and you can uproot problems rather than mask them.
  5. Neglecting expert insight: Just as expert ophthalmologists identified and tackled the woman’s rare case, specialized consultants can guide your strategy where you lack internal capacity.

How Can Startups Protect Their “Health”?

If I could offer a specific action plan, it would look like this:

  • Build preventive measures: Partner wisely with suppliers and collaborators whose values align, reducing dependency risks.
  • Create a “diagnostic roadmap”: Define when your introspection moments should happen. At CADChain, for example, quarterly audits helped us eliminate small inefficiencies before they affected our trajectory.
  • Education and community matter in health, and business: Just like recognizing the signs of infection, learning new skills such as AI for startups, or exchanging authentic feedback with business communities, opens alternative pathways for growth.

Wrapping Up: Every Lump Could Mean Something

In this unusual story, the woman never knew a lump caused by a mosquito bite would turn into something alarming. That’s the reality of risk in life, just like it is in business ventures. When growing a business or tackling an unknown market, vigilance coupled with rapid interventions is necessary for staying ahead of every shift.

Being a startup founder comes with challenges no glossy motivation quote can prepare you for, and that’s fine. The goal is to thrive, adapt, and inspect your risks before they balloon into costly problems, whether on your skin or in your business.

FAQ

1. What happened to the woman with the four-inch worm in her forehead?
She noticed a hard lump in her right temple, which turned out to be a four-inch-long worm that traveled to her left eyelid. The worm was surgically removed by ophthalmologists in Romania. Read more about the case at Ars Technica

2. What parasite was the worm identified as?
The worm was identified as Dirofilaria repens, a parasitic roundworm typically transmitted through mosquito bites. It primarily infects dogs and wild animals but can occasionally infect humans. Learn about Dirofilaria from the CDC

3. How do humans become infected with Dirofilaria repens?
Humans become infected through mosquito bites. The mosquitoes transmit the larvae of the parasite, which then grow into adult worms under the skin.

4. How is this condition treated in humans?
The primary treatment for D. repens infection in humans is surgical removal of the worm. In some cases, medications, including antiparasitic or anti-inflammatory drugs, may be used as a precaution. Read more in the NEJM Case Report

5. Are humans common hosts for Dirofilaria repens?
No, humans are considered “dead-end hosts” for this parasite. While rare, the larvae can develop under human skin, but they cannot complete their life cycle as in their usual animal hosts like dogs.

6. Why is Dirofilaria repens emerging in new regions?
Climate change and globalization are believed to be factors in the northward and eastward expansion of D. repens. For example, it has been reported in regions like Estonia and Lithuania. Check out the CDC Case Report on Expansion to Estonia

7. What symptoms did the woman experience?
The patient initially noticed a nodule on her temple, which later moved to her eyelid. She experienced swelling, redness, and a visible moving worm under her skin.

8. Should dog owners be concerned?
Yes, dog owners in endemic regions should be aware of the risk. D. repens primarily infects dogs, and transmission is possible when bitten by mosquitoes carrying the parasite. Prevention methods include mosquito control measures.

9. What should someone do if they notice a strange nodule on their skin?
Any unusual lump, especially if it appears to move or changes location, should be examined by a medical professional as it could be indicative of a parasitic infection or another medical condition.

10. Is this the first reported case of Dirofilaria repens in humans?
No, but Dirofilaria repens infections in humans are rare. There have been increased reports of human cases in recent years, potentially due to expanding habitats of the parasite and carrier species. Explore the Microorganisms Journal case in Austria

About the Author

Violetta Bonenkamp, also known as MeanCEO, is an experienced startup founder with an impressive educational background including an MBA and four other higher education degrees. She has over 20 years of work experience across multiple countries, including 5 years as a solopreneur and serial entrepreneur. Throughout her startup experience she has applied for multiple startup grants at the EU level, in the Netherlands and Malta, and her startups received quite a few of those. She’s been living, studying and working in many countries around the globe and her extensive multicultural experience has influenced her immensely.

Violetta Bonenkamp's expertise in CAD sector, IP protection and blockchain

Violetta Bonenkamp is recognized as a multidisciplinary expert with significant achievements in the CAD sector, intellectual property (IP) protection, and blockchain technology.

CAD Sector:

  • Violetta is the CEO and co-founder of CADChain, a deep tech startup focused on developing IP management software specifically for CAD (Computer-Aided Design) data. CADChain addresses the lack of industry standards for CAD data protection and sharing, using innovative technology to secure and manage design data.
  • She has led the company since its inception in 2018, overseeing R&D, PR, and business development, and driving the creation of products for platforms such as Autodesk Inventor, Blender, and SolidWorks.
  • Her leadership has been instrumental in scaling CADChain from a small team to a significant player in the deeptech space, with a diverse, international team.

IP Protection:

  • Violetta has built deep expertise in intellectual property, combining academic training with practical startup experience. She has taken specialized courses in IP from institutions like WIPO and the EU IPO.
  • She is known for sharing actionable strategies for startup IP protection, leveraging both legal and technological approaches, and has published guides and content on this topic for the entrepreneurial community.
  • Her work at CADChain directly addresses the need for robust IP protection in the engineering and design industries, integrating cybersecurity and compliance measures to safeguard digital assets.

Blockchain:

  • Violetta’s entry into the blockchain sector began with the founding of CADChain, which uses blockchain as a core technology for securing and managing CAD data.
  • She holds several certifications in blockchain and has participated in major hackathons and policy forums, such as the OECD Global Blockchain Policy Forum.
  • Her expertise extends to applying blockchain for IP management, ensuring data integrity, traceability, and secure sharing in the CAD industry.

Violetta is a true multiple specialist who has built expertise in Linguistics, Education, Business Management, Blockchain, Entrepreneurship, Intellectual Property, Game Design, AI, SEO, Digital Marketing, cyber security and zero code automations. Her extensive educational journey includes a Master of Arts in Linguistics and Education, an Advanced Master in Linguistics from Belgium (2006-2007), an MBA from Blekinge Institute of Technology in Sweden (2006-2008), and an Erasmus Mundus joint program European Master of Higher Education from universities in Norway, Finland, and Portugal (2009).

She is the founder of Fe/male Switch, a startup game that encourages women to enter STEM fields, and also leads CADChain, and multiple other projects like the Directory of 1,000 Startup Cities with a proprietary MeanCEO Index that ranks cities for female entrepreneurs. Violetta created the "gamepreneurship" methodology, which forms the scientific basis of her startup game. She also builds a lot of SEO tools for startups. Her achievements include being named one of the top 100 women in Europe by EU Startups in 2022 and being nominated for Impact Person of the year at the Dutch Blockchain Week. She is an author with Sifted and a speaker at different Universities. Recently she published a book on Startup Idea Validation the right way: from zero to first customers and beyond, launched a Directory of 1,500+ websites for startups to list themselves in order to gain traction and build backlinks and is building MELA AI to help local restaurants in Malta get more visibility online.

For the past several years Violetta has been living between the Netherlands and Malta, while also regularly traveling to different destinations around the globe, usually due to her entrepreneurial activities. This has led her to start writing about different locations and amenities from the POV of an entrepreneur. Here’s her recent article about the best hotels in Italy to work from.

About the Publication

Fe/male Switch is an innovative startup platform designed to empower women entrepreneurs through an immersive, game-like experience. Founded in 2020 during the pandemic "without any funding and without any code," this non-profit initiative has evolved into a comprehensive educational tool for aspiring female entrepreneurs.The platform was co-founded by Violetta Shishkina-Bonenkamp, who serves as CEO and one of the lead authors of the Startup News branch.

Mission and Purpose

Fe/male Switch Foundation was created to address the gender gap in the tech and entrepreneurship space. The platform aims to skill-up future female tech leaders and empower them to create resilient and innovative tech startups through what they call "gamepreneurship". By putting players in a virtual startup village where they must survive and thrive, the startup game allows women to test their entrepreneurial abilities without financial risk.

Key Features

The platform offers a unique blend of news, resources,learning, networking, and practical application within a supportive, female-focused environment:

  • Skill Lab: Micro-modules covering essential startup skills
  • Virtual Startup Building: Create or join startups and tackle real-world challenges
  • AI Co-founder (PlayPal): Guides users through the startup process
  • SANDBOX: A testing environment for idea validation before launch
  • Wellness Integration: Virtual activities to balance work and self-care
  • Marketplace: Buy or sell expert sessions and tutorials

Impact and Growth

Since its inception, Fe/male Switch has shown impressive growth:

  • 5,000+ female entrepreneurs in the community
  • 100+ startup tools built
  • 5,000+ pieces of articles and news written
  • 1,000 unique business ideas for women created

Partnerships

Fe/male Switch has formed strategic partnerships to enhance its offerings. In January 2022, it teamed up with global website builder Tilda to provide free access to website building tools and mentorship services for Fe/male Switch participants.

Recognition

Fe/male Switch has received media attention for its innovative approach to closing the gender gap in tech entrepreneurship. The platform has been featured in various publications highlighting its unique "play to learn and earn" model.